Recent autopsy documents reveal that the actor had been undergoing testosterone shots, a factor believed to be contributing to his reported behavior of being "angry and mean" in the weeks leading up to his death.
From OK! Magazine:
On top of divulging the star’s cause of death was the acute effects of ketamine, the report also shared Perry had been on an opioid-like drug buprenorphine, which is used to curb pain and help with addiction to opioids, as well as Tammoxifen to lose weight, an antidiabetic medication and nicotine lollipops.
Additionally, Perry was attempting to quit smoking at the time of his death, however, his assistant noted he had been smoking about two packs of cigarettes per day.
“In the assistant’s bedroom, there were multiple open, empty, half-filled medication bottles prescribed to the decedent, as well as over-the-counter medications, vitamins, digestive aids and dishes filled with multiple various loose pills, tablets, caplets, candy and breath mints,” the medical examiner wrote.
“Prescribed ointments, digestive aids and oral rinses” were found in Perry’s bathroom.
The sitcom actor was also receiving ketamine infusions regularly before his passing, however, the dose that killed him was seemingly self-administered.
Matthew had a lengthy history of grappling with substance abuse, so the notion that it adversely impacted his state of mind, ultimately culminating in his death, isn't entirely far-fetched.
Nevertheless, it remains profoundly tragic to witness how he essentially cast his life aside for the sake of drugs.